Hairloss PI

Posts Tagged ‘androgenetic alopecia’

The role of inflammation and immunity in the pathogenesis of androgenetic alopecia.

Magro CM, Rossi A, Poe J, Manhas-Bhutani S, Sadick N.

Abstract

Background: Female pattern hair loss affects many women; its pathogenetic basis has been held to be similar to men with common baldness.

Objective: The objective of this study was to determine the role of immunity and inflammation in androgenetic alopecia in women and modulate therapy according to inflammatory and immunoreactant profiles. Materials and

Methods: 52 women with pattern hair loss (AA) underwent scalp biopsies for microscopic assessment and immunofluroescent studies.

In 18 patients, serologic assessment for antibodies to androgen receptor, estrogen receptor and cytokeratin 15 was conducted.

Results: A lymphocytic folliculitis targeting the bulge epithelium was observed in many cases.

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If you’ve have had the suspicion that you were going bald, you probably have had a strong need to figure out just what is “happening under the hood.” There is a sea of rumors floating out there that attempt to explain the “root” of the problem. After all, the great Hippocrates, father of modern medicine, thought that baldness could be cured by a mixture containing horseradish and pigeon droppings. The desire to have a simple solution -– particularly one that is within our control –- is understandable. But today, let’s debunk some of these myths and learn what the facts really are.

Myth #1

Genes for hair loss come only from the mother’s side of the family.

Fact: Although the inheritance from the mother’s side is slightly stronger, androgenetic hair loss (common baldness) can be inherited from the mother’s side of the family, the father’s side –- or both.

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